PIKIÄ®¹ is a proprietary micro-molecular vegan collagen developed through frontier biotechnology research. By using AI to analyze vast amounts of protein data found in nature, we engineered a molecular structure designed for high compatibility with human skin. PIKIÄ®¹ has an amino acid sequence 100% identical² to the collagen naturally found in skin.
These ultra-fine collagen peptides are absorbed seamlessly throughout the skin as though syncing with its natural rhythm. Trusted by luxury spas around the world, MIROS is the first³ brand in Japan to formulate with PIKIÄ®¹ .
*1 sh-Polypeptide-47 (Skin-conditioning agent)
*2 Collagen Type I
*3 Based on the ingredient supply agreement between Sancta Co.Ltd. and Cambrium GmbH (Germany), the manufacturer of PIKIÄ® (as of January 2026). PIKIÄ® is formulated in cosmetics in Japan for the first time in the four MIROS skincare products: Hydrating Treatment Lotion, Infusion Emulsion, Serum 8, and Radiance Cream.
Proprietary Collagen PIKIÄ®
“The Architect of Beauty”
"PIKIÄ®¹, MIROS's proprietary beauty ingredient, is what we call 'The Architect of Beauty.'
Rather than treating the skin at its surface, we look to the structures that shape its very impression.
Guided by our molecular design approach, we analyzed vast protein data from the natural world with AI — reading molecular configurations and interactions like blueprints — to derive a precise design attuned to the skin's environment.
From this philosophy, precision fermentation gave rise to a micro-molecular collagen whose amino acid sequence is 100% identical² to that of human skin.
PIKIÄ®¹ works in concert with the skin's fundamental architecture — the quiet center of a composed, refined complexion."
A Molecular Design Approach
AI Design
Rather than relying on conventional discovery methods, was deliberately engineered through a precision molecular design process. AI analyzes vast protein sequence data derived from nature to engineer highly precise molecular structures. Desired performance characteristics are defined upfront, and promising candidates are refined through simulation and validation. This enables the design of next-generation materials guided by efficacy, precision, and scalability.
Precision Fermentation
Guided by insights derived from AI design, fermentation conditions are precisely controlled to minimize molecular variability. This manufacturing technology enables the continuous production of materials defined by uniformity, stability, and uncompromising quality.
100% Skin-identical
Mirrors the amino acid sequence of type I collagen, PIKIÄ®*¹ offers exceptional compatibility with our skin.
Micro-molecular
Its small size allows for seamless absorption and a refined sensory experience.
100% Vegan
Developed through precision fermentation without animal-derived ingredients, reflecting a commitment to clean and ethical formulation.
The Genesis: A Chance Meeting in New York
Headquartered in Germany, Cambrium develops next-generation materials using synthetic biology and AI-driven molecular imaging techniques. The company is backed by leading global investors, including Google’s AI-focused venture arm, and focuses on computational approaches to building bio-based materials.
A chance meeting in New York between Cambrium’s CEO, Mitchell Duffy, and MIROS founder Eita Nakagawa became the spark that led to the creation of MIROS and laid the foundation for its molecular design approach.
Mitchell Duffy (right), CEO of Cambrium
Eita Nakagawa (left), Founder of MIROS
BERLIN, GERMANY – OCT 2025
CONVERSATION
Eita - The cycles of regeneration inherent in the natural world have always been my primary source of inspiration. I am deeply grateful that my curiosity for science and my profound respect for nature have led me to collaborate with the world’s leading biotechnology team.
Mitchell - At Cambrium we use AI to design and build novel proteins.
We’re creating a new material world using nature’s building blocks.
We began by reimagining one of the most ancient and abundant proteins: collagen.
Eita - In skincare, collagen is essential. It gives our skin a youthful impression.
When I heard Cambrium designed a collagen identical to our own skin, I was instantly drawn in.
Mitchell - We built Cambrium to reimagine and transform industries, beginning with skincare.
Through MIROS, Eita is bringing this holistic vision to life.
Eita - I was inspired by timeless Japanese principles.
But what fascinates me is how this technology can unite something so deeply rooted in tradition, with the materials of the future.
Mitchell - Focusing on collagen—the most abundant protein in the extracellular matrix—we have successfully leveraged AI to decode the blueprints of molecular evolution spanning millions of years. Guided by these blueprints and powered by precision fermentation, we have created a 100% vegan, nano-sized collagen that possesses a sequence identical to that of human skin. This unique collagen has the power to restore and optimize the skin’s inherent condition.
Beauty Guided by Intelligence of the Future
For all who live each day with intention.
MIROS unites frontier biotechnology with traditional Japanese botanicals and fermentation-derived ingredients to create formulations that are both high-performance and sustainable. At the core of every MIROS skincare creation lies PIKIÄ®*¹, a 100% skin-identical vegan collagen, complemented by carefully selected Japanese traditional ingredientsand botanicals*² such as Rice Ferment Extract, White Lavender, Yukinoshita, and Irohamomiji Maple leaf extract.